Role for y-Aminobutyric Acid in Selective Vulnerability in Gerbils
نویسندگان
چکیده
We tested the efficacy of various putative neuroprotective agents in the gerbil model of delayed neuronal death. The selective loss of anterior CA1 neurons of the hippocampus 4 days after 5 minutes of bilateral ischemia was complete in >90% of the gerbils examined. We tested 11 agents for their ability to protect against neuronal loss. Only those agents that were associated with the GABAergic system exhibited protection and only when administered before the ischemic insult. The possibility that delayed neuronal death is the result of a primary defect in inhibitory neurotransmission is considered. (Stroke 1989;20:281-287)
منابع مشابه
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The objective of this study was to investigate the role of β-aminobutyric acid(BABA) (0, 300µM) in reduction of oxidative damages in leaves and roots of Brassica napus L. under drought stress (0, -0.2, -0.4 MPa). β-aminobutyric acid was investigated as an internal regulator hormone and its role in defense mechanisms against biotic and abioticstresses. In this study, BABA pretreatment prevented...
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